RIPK2 inhibitor OD36

Research use only, not for human use.

RIPK2 inhibitor OD36 is a potent, specific, ATP-competitive inhibitor of RIPK2 with IC50 of 5.3 nM.

RIPK2 inhibitor OD36 is a potent, specific, ATP-competitive inhibitor of RIPK2 with IC50 of 5.3 nM, inhibits Tyr and Ser/Thr-directed activities of RIPK2; inhibits both RIPK2 tyrosine autophosphorylation as well as downstream NF-κB and MAPK signaling induced by MDP, downregulates a panel of RIPK2 kinase-dependent genes; reduces cellular infiltration in an in vivo MDP-induced peritonitis model; also shows high affinity for cyclin G-associated kinase (GAK) with Ki of 3.8 nM.

OD36; OD-36; OD 36

Apoptosis

RIP kinase

RIP kinase

——

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1638644-62-8

330.77

C16H15ClN4O2

>98% (HPLC)

——

ClC1=CC(C2=C3N=C(C=CN3N=C2)NCCOCCO4)=CC4=C1

(13Z,14E)-25-chloro-3,6-dioxa-9-aza-1(3,5)-pyrazolo[1,5-a]pyrimidina-2(1,3)-benzenacyclononaphane

(-20℃)

With Ice Pack

≥ 2 years