
RIPK2 inhibitor OD36
CAS No. 1638644-62-8
RIPK2 inhibitor OD36( OD36 | OD-36 | OD 36 )
Catalog No. M12475 CAS No. 1638644-62-8
RIPK2 inhibitor OD36 is a potent, specific, ATP-competitive inhibitor of RIPK2 with IC50 of 5.3 nM.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 393 | Get Quote |
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10MG | 581 | Get Quote |
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25MG | 888 | Get Quote |
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50MG | 1242 | Get Quote |
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100MG | 1674 | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameRIPK2 inhibitor OD36
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NoteResearch use only, not for human use.
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Brief DescriptionRIPK2 inhibitor OD36 is a potent, specific, ATP-competitive inhibitor of RIPK2 with IC50 of 5.3 nM.
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DescriptionRIPK2 inhibitor OD36 is a potent, specific, ATP-competitive inhibitor of RIPK2 with IC50 of 5.3 nM, inhibits Tyr and Ser/Thr-directed activities of RIPK2; inhibits both RIPK2 tyrosine autophosphorylation as well as downstream NF-κB and MAPK signaling induced by MDP, downregulates a panel of RIPK2 kinase-dependent genes; reduces cellular infiltration in an in vivo MDP-induced peritonitis model; also shows high affinity for cyclin G-associated kinase (GAK) with Ki of 3.8 nM.
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In VitroOD36 also inhibits ALK2 and ALK2 R206H with IC50s of 47 and 22 nM, respevtively.OD36 shows activity against ALK1 with a KD of 90 nM.OD36 potently antagonize mutant ALK2 signaling and osteogenic differentiation.OD36 (0.1-1 μM; 24 h) efficiently inhibits BMP-6 (50 ng/mL)-induced p-Smad1/5 in KS483 cells.Preincubation of fibrodysplasia ossificans progressiva (FOP) endothelial colony-forming cells (ECFCs) with OD36 (0.5 μM) completely prevents the activation of Smad1/5 and gene targets ID-1 and ID-3 in response to activin A.Western Blot Analysis Cell Line:KS483 cells Concentration:0.1, 0.2, and 1 μM Incubation Time:Result:Inhibited BMP-6 induced p-Smad1/5.
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In VivoOD36 (6.25 mg/kg; i.p.; once) alleviates inflammation in an acute peritonitis mice model. Animal Model:C57BL/6 mice, muramyl dipeptide (MDP)-induced model of peritonitisDosage:6.25 mg/kg Administration:Intraperitoneal injection, 30 min prior to MDP Result:Inhibited the recruitment of inflammatory cells to the peritoneum, specifically that of neutrophils, and, to a lesser extent, lymphocytes. Decreased RIPK2-specific genes as well as inflammatory cytokine and chemokine gene expression.
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SynonymsOD36 | OD-36 | OD 36
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PathwayApoptosis
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TargetRIP kinase
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RecptorRIP kinase
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Research Area——
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Indication——
Chemical Information
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CAS Number1638644-62-8
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Formula Weight330.772
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Molecular FormulaC16H15ClN4O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 33.33 mg/mL (100.76 mM)
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SMILESClC1=CC(C2=C3N=C(C=CN3N=C2)NCCOCCO4)=CC4=C1
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Chemical Name(13Z,14E)-25-chloro-3,6-dioxa-9-aza-1(3,5)-pyrazolo[1,5-a]pyrimidina-2(1,3)-benzenacyclononaphane
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tigno-Aranjuez JT, et al. J Biol Chem. 2014 Oct 24;289(43):29651-64.
2. Asquith CRM, et al. J Med Chem. 2019 Feb 15. doi: 10.1021/acs.jmedchem.8b01213.
molnova catalog



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